Pancuronium
Generic name: Pancuronium bromide
Dosage form: injection, solution
Drug class:Neuromuscular blocking agents
Medically reviewed by Drugs.com. Last updated on Dec 22, 2021.
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10 mg/10 mL (1 mg/mL)
Fliptop Vial
Rx only
Pancuronium Description
Pancuronium Bromide is a nondepolarizing neuromuscular blocking agent chemically designated as the aminosteroid 2β, 16β - dipiperidino-5α-androstane-3α, 17-β diol diacetate dimethobromide, C35H60Br2N2O4. It is a fine white odorless powder which is soluble in water, alcohol and chloroform.
It has the following structural formula:
Pancuronium Bromide Injection, USP is available in sterile, isotonic, nonpyrogenic solution for injection. Each mL contains Pancuronium bromide 1 mg; sodium acetate, anhydrous 1.2 mg; benzyl alcohol 10 mg as preservative. Sodium chloride added to adjust tonicity. May contain acetic acid and/or sodium hydroxide for pH adjustment. pH is 4.0 (3.8 to 4.2).
Pancuronium - Clinical Pharmacology
Pancuronium bromide is a nondepolarizing neuromuscular blocking agent possessing all of the characteristic pharmacological actions of this class of drugs (curariform). It acts by competing for cholinergic receptors at the motor end-plate. The antagonism to acetylcholine is inhibited; and neuromuscular block is reversed by anticholinesterase agents such as pyridostigmine, neostigmine, and edrophonium. Pancuronium bromide is approximately 1/3 less potent than vecuronium and approximately 5 times as potent as d-tubocurarine: the duration of neuromuscular blockage produced by Pancuronium bromide is longer than that of vecuronium at initially equipotent doses.
The ED95 (dose required to produce 95% suppression of muscle twitch respons..
